The plane, a Continental Connection flight operated by Colgan Air, was on a flight from Newark, New Jersey, to Buffalo with 44 passengers and four crew on board when it crashed in the Buffalo suburb of Clarence Center amid rain and sleet, the Federal Aviation Administration (FAA) said.
Erie County Executive Chris Collins said all 48 people on board the plane were killed. One person was killed in the house while two others escaped with minor injuries, he said.
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"At this point there is no information whatsoever as to what the cause may be," Collins told a news conference early on Friday. He said the control tower lost contact with the plane before it landed but officials knew of no trouble.
Clarence Town supervisor Scott Bylewski told reporters: "I did hear what sounded like a door slamming ... I then went outside of my own house and could see that the sky was red."
